Tobias Meyer, Ph.D.
Joseph Hinsey Professor of Cell and Developmental Biology
I am interested in how cells coordinate the cell cycle and cell migration during tissue regeneration. I want to measure the dynamics of various signaling pathways using genetically encoded sensors and optogenetic tools.
The composition of the cellular lipid landscape is essential for the regulation of biological processes. Previously, the functional annotation of membrane lipids in macrophages led to the identification of lipid species differentially regulating receptor signaling. Cell migration and cell division are both fundamental processes that are precisely regulated by conserved signaling pathways combined with the availability of metabolites. My research is centered around the identification of metabolic pathways and specific metabolites regulating cell cycle progression and migration.
I am interested in how cells integrate membrane contact signals to control cell movements.
I am interested in understanding the relationship between cell polarization and proliferation.
My research focuses on how stochastic levels of endogenous cellular stress impact cell cycle dynamics and the proliferation decision.
I am interested in how growth factor receptor signaling is regulated as cells undergo contact inhibition of proliferation, particularly in relation to cell junctional complexes and the cytoskeleton.
I study how cells regulate and prepare for DNA replication. In particular, I am interested in how cells coordinate the transition from G1, where cells prepare for DNA replication while robustly avoiding premature DNA synthesis, to S phase of the cell cycle.
I am interested in understanding the regulation of the transcription factor E2F outside of the cell cycle.
I am interested in the temporal regulation of the G1/S phase transition and mechanisms of quiescence exit.