The Meyer lab seeks to understand how human cells move and divide to build, maintain and repair tissues and organs. The movement and division of cells is controlled by integration of large numbers of mitogen, cell contact, and stress signaling inputs that control the maintenance and repair of tissues and drive cancer progression. We are identifying new targets for cancer therapy and seek new ways to promote tissue repair by developing and applying cutting edge live-cell microscopy approaches to understand how signaling systems orchestrate cell movement and proliferation of normal and cancer cells.
The paper shows that cells can live without Cdc7 but then need Cdk1 instead of Cdk2 to start S phase
Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration
Intravital imaging reveals cell cycle-dependent satellite cell migration during muscle regeneration
Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation
Depts. of Cell and Developmental Biology and Biochemistry
Weill Cornell Medicine
1300 York Ave, Rm402
New York, NY
tom4003@med.cornell.edu
