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CDC7-independent G1/S transition revealed by targeted protein degradation

Jan M Suski, Nalin Ratnayeke ... Tobias Meyer*, Piotr Sicinski*. Nature. 2022 May 4. doi: 10.1038/s41586-022-04698-x (*corresponding authors)

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A parallel cell-cycle entry pathway with inverted G1 signaling and alternate point of no return

Liu C, Konagaya Y, Chung M, Daigh LH, Fan Y, Yang HW, Terai K, Matsuda M, & Meyer T. 2020. Nature Communications 11, 5305

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Membrane proximal F-actin restricts local membrane protrusions and directs cell migration.

Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Science 2020 Jun 12 DOI: 10.1126/science.aay7794

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T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration

Damien Garbett, Anjali Bisaria, Changsong Yang, Dannielle G. McCarthy, Arnold Hayer, W. E. Moerner, Tatyana M. Svitkina & Tobias Meyer 2020. Nature Communications, 11, 4818.

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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1

Chung M, Liu C, Yang HW, Köberlin MS, Cappell SD, & Meyer T. Molecular Cell 2019 Sept 19. doi: https://doi.org/10.1016/j.molcel.2019.08.020

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An intrinsic S/G2 checkpoint enforced by ATR

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. Science. 2018 Aug 24 DOI: 10.1126/science.aap9346 PMC6365305.

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EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T. Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0199-7. PubMed PMID:29875408.

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Competing memories of mitogen and p53 signalling control cell-cycle entry.

Yang HW, Chung M, Kudo T, Meyer T. Nature. 2017 Sept 21. doi: 10.1038/nature23880 PubMed PMID:28869970.

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Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.

Hayer A, Shao L, Chung M, Jouber LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T. Nat Cell Biol. 2016 Nov 14. doi: 10.1038/ncb3438 PubMed PMIDL27842057

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Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.

Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Cell. 2016 Jun 30. doi: 10.1016/j.cell.2016.05.077. PubMed PMID:27368103.

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Locally excitable Cdc42 signals steer cells during chemotaxis.

Yang HW*, Collins SR*, Meyer T. Nat Cell Biol. 2016 Feb 18. doi: 10.1038/ncb3292. PubMed PMID:26689677.

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Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation.

Winans AM, Collins SR, Meyer T. Elife. 2016 Feb 2. doi: 10.7554/eLife.12387. PubMed PMID:26836307.

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A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration.

Tsai FC, Seki A, Yang HW, Hayer A, Carrasco S, Malmersjö S, Meyer T. Nat Cell Biol. 2014 Feb. doi: 10.1038/ncb2906. PubMed PMID:24463606.

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The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit.

Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. Cell. 2013 Oct 10;155(2):369-83. doi: 10.1016/j.cell.2013.08.062. Epub 2013 Sep 26.

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CDC7-independent G1/S transition revealed by targeted protein degradation

Jan M Suski, Nalin Ratnayeke ... Tobias Meyer*, Piotr Sicinski*. Nature. 2022 May 4. doi: 10.1038/s41586-022-04698-x (*corresponding authors)

Publication Image

A parallel cell-cycle entry pathway with inverted G1 signaling and alternate point of no return

Liu C, Konagaya Y, Chung M, Daigh LH, Fan Y, Yang HW, Terai K, Matsuda M, & Meyer T. 2020. Nature Communications 11, 5305

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Membrane proximal F-actin restricts local membrane protrusions and directs cell migration.

Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Science 2020 Jun 12 DOI: 10.1126/science.aay7794

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Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

Yang HW, Cappell SD, Jaimovich A, Liu C, Chung M, Daigh LH, Pack LR, Fan Y, Regot S, Covert M, Meyer T. eLife 2020 Apr 7 .DOI: 10.7554/eLife.44571. PMC7213986

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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1

Chung M, Liu C, Yang HW, Köberlin MS, Cappell SD, & Meyer T. Molecular Cell 2019 Sept 19. doi: https://doi.org/10.1016/j.molcel.2019.08.020

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Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization

Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA. Dev Cell. 2019 Apr 22. 49, 189-205. DOI: 10.1016/j.devcel.2019.03.025 PMC6708378.

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An intrinsic S/G2 checkpoint enforced by ATR

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. Science. 2018 Aug 24 DOI: 10.1126/science.aap9346 PMC6365305.

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EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T. Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0199-7. PubMed PMID:29875408.

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Competing memories of mitogen and p53 signalling control cell-cycle entry.

Yang HW, Chung M, Kudo T, Meyer T. Nature. 2017 Sept 21. doi: 10.1038/nature23880 PubMed PMID:28869970.

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Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.

Hayer A, Shao L, Chung M, Jouber LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T. Nat Cell Biol. 2016 Nov 14. doi: 10.1038/ncb3438 PubMed PMIDL27842057

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Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.

Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Cell. 2016 Jun 30. doi: 10.1016/j.cell.2016.05.077. PubMed PMID:27368103.

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Locally excitable Cdc42 signals steer cells during chemotaxis.

Yang HW*, Collins SR*, Meyer T. Nat Cell Biol. 2016 Feb 18. doi: 10.1038/ncb3292. PubMed PMID:26689677.

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Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation.

Winans AM, Collins SR, Meyer T. Elife. 2016 Feb 2. doi: 10.7554/eLife.12387. PubMed PMID:26836307.

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A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration.

Tsai FC, Seki A, Yang HW, Hayer A, Carrasco S, Malmersjö S, Meyer T. Nat Cell Biol. 2014 Feb. doi: 10.1038/ncb2906. PubMed PMID:24463606.

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The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit.

Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. Cell. 2013 Oct 10;155(2):369-83. doi: 10.1016/j.cell.2013.08.062. Epub 2013 Sep 26.

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Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.

Wollman R, Meyer T. Nat Cell Biol. 2012 Dec;14(12):1261-9. doi: 10.1038/ncb2614. Epub 2012 Nov 11.

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External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.

Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T. Nat Cell Biol. 2012 Aug;14(8):874-81. doi: 10.1038/ncb2533. Epub 2012 Jul 1.

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Spatial positive feedback at the onset of mitosis.

Santos SD, Wollman R, Meyer T, Ferrell JE Jr. Cell. 2012 Jun 22;149(7):1500-13. doi: 10.1016/j.cell.2012.05.028.

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A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.

Chen JY, Lin JR, Cimprich KA, Meyer T. Mol Cell. 2012 Jan 27;45(2):196-209. doi: 10.1016/j.molcel.2011.11.023. Epub 2011 Dec 28.

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Modular control of endothelial sheet migration.

Vitorino P, Meyer T. Genes Dev. 2008 Dec 1;22(23):3268-81. doi: 10.1101/gad.1725808.

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Feedback loops shape cellular signals in space and time.

Brandman O, Meyer T. Feedback loops shape cellular signals in space and time. Science. 2008 Oct 17;322(5900):390-5. doi: 10.1126/science.1160617.

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STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.

Brandman O, Liou J, Park WS, Meyer T. STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca(2+) Levels. Cell. 2007 Dec 28; 131(7):1327-29.

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Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

Liou, J., Fivaz, M., Inoue, T., and T. Meyer. 2007. Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9301-6. Epub 2007 May 21.

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PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Heo, W.D., Inoue, T., Park, W.S., Kim, M.L., Park, B.O., Wandless, T.J., and T. Meyer. 2006. PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science. 314(5804):1458-61.

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Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.

Suh, B.C., Inoue, T., Meyer, T., and B. Hille. 2006. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science. 314(5804):1454-7.

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Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Brandman, O., Ferrell, J.E. Jr, Li, R., and T. Meyer. 2005. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310(5747):496-8.

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STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

Liou, J., Kim, M.L., Heo, W.D., Jones, J.T., Myers, J.W., Ferrell, J.E. Jr, and T. Meyer. 2005. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 15(13):1235-41.

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An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.

Inoue, T., Heo, W.D., Grimley, J.S., Wandless, T.J.,and T. Meyer. 2005. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods. 2(6):415-8.

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A Local Coupling Model and Compass Parameter for Eukaryotic Chemotaxis.

Arrieumerlou, C. and T. Meyer. 2005. A Local Coupling Model and Compass Parameter for Eukaryotic Chemotaxis. Developmental Cell vol. 8: 215-227.