Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons. In the vertebrate central nervous system, exploratory filopodia transiently form on dendritic branches to sample the neuronal environment and initiate new trans-neuronal contacts. While much is known about the molecules that control filopodia extension and subsequent maturation into […]

Congratulations to Sean who got a position in UC Davis and to Sabrina who is opening her lab in UC Boulder. Good luck in your new labs!

A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration. Ca(2+) signals control cell migration by regulating forward movement and cell adhesion. However, it is not well understood how Ca(2+)-regulatory proteins and second messengers are spatially organized in migrating cells. Here we show that receptor tyrosine kinase and phospholipase C signalling are restricted […]

Contratulations to Milos who got a position in the Universität Münster. Good luck in your new lab!