Chad and Min Graduated!

Chad is starting a Postdoc in the Discovery Oncology Lab at Genentech and Min is starting a Postdoc in the Rando Lab at Stanford. Good luck to you both!

Min successfully defended!

Congratulations Dr. Chung!

Lin’s paper got a News & Views and Editor’s Choice at Science

GPCRs join the mTORC1 regulatory network Rag GTPases play a crucial role in mTORC1 activation by promoting its recruitment to the lysosomal surface in a nutrient-dependent manner. A study now identifies a family of lysosomal G-protein-coupled receptors as modulators of Rag GTPases localization and activation, adding one more component to the fast-growing mTOR regulatory network. […]

Lin’s paper is out in Nature Cell Biology

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity Cell growth is controlled by a lysosomal signalling complex containing Rag small GTPases and mammalian target of rapamycin complex 1 (mTORC1) kinase. Here, we carried out a microscopy-based genome-wide human short interfering RNA screen and discovered a lysosome-localized G protein-coupled receptor (GPCR)-like protein, […]

The Lab Goes Bioluminescent Kayaking @ Point Reyes

The Lab traveled to Pt. Reyes to go hiking, birding and bioluminescent kayaking for Chad’s farewell party!

Chad Successfully Defended!

Congratulations Dr. Liu!

Chad’s paper is up on BiorXiv!

A parallel cell-cycle entry pathway with inverted G1 signaling and alternate point of no return Cell-cycle entry relies on an orderly progression of signaling events. To start, cells first activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma protein Rb. Hours later, cells inactivate APC/CCDH1¬†and cross the final commitment point. However, […]

The Lab Goes Surfing!

The lab took surfing lessons as a farewell party for Hee Won!

Hee Won is opening his own lab!

Congratulations to Hee Won who is opening a new lab at Columbia University in the Department of Pathology and Cell Biology starting in 2019.

Steve’s paper is out in Nature

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle Mammalian cells integrate mitogen and stress signalling before the end of G1 phase to determine whether or not they enter the cell cycle. Before cells can replicate their DNA in S phase, they have to activate cyclin-dependent kinases (CDKs), […]